The aim of this study was to compare the effectiveness of treatment and commitment based on acceptance and commitment and cognitive-behavioral improvement in cognitive impairment, emotional tolerance and social well-being in patients with colorectal cancer. The experimental study and the study population were all patients with colorectal cancer in Ardabil province. The statistical population of the present study consisted of all cancer patients who referred to hospitals in Ardabil province in the second half of 2019. The sampling method of the present study was available as a sample. A sample of 48 patients with cancer was selected from patients referred to clinics and randomly assigned to three groups; (16 people were accepted for treatment based on acceptance and commitment, 16 people for cognitive-behavioral therapy, 16 people for the control group). Critical distortion questionnaires, emotional tolerance questionnaires, and social welfare questionnaires were used to measure the variables studied. And in order to analyze the hypotheses, (Manova multivariate analysis of variance) was used. The findings of this study showed that both treatment methods (treatment methods based on acceptance and commitment and cognitive-behavioral) are effective in improving cognitive distortion, emotional tolerance and social well-being of patients with colorectal cancer. However, the effectiveness of cognitive-behavioral psychotherapy is more than acceptance-based psychotherapy. Due to the improvement of cognitive impairment, emotional tolerance, and social well-being in the two experimental groups, it can be said that psychotherapy methods based on acceptance and commitment and cognitive-behavioral have been effective in patients. In other words, these two methods of psychotherapy, along with other therapies such as medication, can be used to improve the psychological state of patients with colorectal cancer.